On May 11, 2011, Hilary Swank was reportedly in talks to join the film with McConaughey's role confirmed.  On October 3, 2012, it was announced that Swank had dropped out of the film and that Gael Garcia Bernal was in talks to play an HIV patient who meets Woodroof in the hospital and helps him in the club.  On November 6, The Hollywood Reporter confirmed that Jared Leto would be returning to acting to play the role which Bernal was previously in talks to play.  In January 2014, Jared Leto has admitted that he was sent a script 15 years ago but never read it.  When Leto was asked about his role, he said: "This was a really special movie. I think it was the role of a lifetime. It's one of the best things I've ever done." He also said that he tried to stay focused on the role because he knew it was an incredible opportunity.  On November 14, Dallas Roberts and Steve Zahn joined the film; Roberts would play David Wayne, Ron's defense attorney, while Zahn would play a Dallas police officer who is sympathetic to Ron.  On November 26, Griffin Dunne , Denis O'Hare , and Bradford Cox joined the cast when the shooting was underway in New Orleans. 
The past 12 months have seen Leland Music not only collaborate with adam&eveDDB on John Lewis' highly anticipated Christmas campaign, reimagining Randy Crawford's 80s classic "One Day I'll Fly Away" with a sense of scale that made it the brand's grandest musical outing to date; they were also responsible for following up C4's London 2012 Paralympics Meet the Superhumans campaign for Rio 2016. No. Mean. Feat. Their bold creative spurred a huge attitudinal shift in public perception towards the Paralympic games, embracing a striking soundtrack that communicated the persistence, commitment and determination embodied by each and every Paralympic athlete: “Yes I Can” (originally performed by Sammy Davis Jnr).